| ncRNA name | OTX2 siRNA |
| ncRNA Category | siRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB cell lines Y79 and WERI; Medulloblastoma cells lines D425MED, D581MED and D324MED |
| Methods | qRT-PCR, immunohistochemistry, immunoblot, siRNA transfection |
| Expression pattern | associated |
| Functional description | Knockdown of OTX2 expression by siRNA or pharmacologic inhibition by all-trans retinoic acid (ATRA) repressed OTX2 expression and cell proliferation and significantly decreased tumor growth in vivo. |
| PubMed ID | 26397460 |
| Year | 2015 |
| Title | OTX2 is a therapeutic target for retinoblastoma and may function as a common factor between C-MYC, CRX, and phosphorylated RB pathways. |
| Drug-related ncRNA | NO |
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